Structure-free
drug discovery

One model for the full human proteome, including disordered targets beyond the reach of structure-based methods.

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Our flagship model for structure-free drug discovery.

01 / Structure-free drug discovery

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Ptarmigan-1

Ptarmigan-1 predicts how proteins and small molecules engage without requiring a 3D structure or a known pocket. Where conventional methods build a structure for each protein-compound pair, Ptarmigan-1 skips folding and places every protein and every compound in one growing landscape where proximity predicts binding.

Inputs
Protein sequence
Small-molecule chemistry
Shared embedding space
OutputsPredicted engagement · Residue position →
Proteins and compounds share an embedding space, where proximity predicts engagement. Illustrative predictions.
01

Reach targets without a 3D structure or a known pocket

Because Ptarmigan-1 never explicitly models a 3D pose, flexible, cryptic, and disordered sites become tractable where structure-based models struggle to represent them.

02

Screen billions of compounds and explore selectivity

Search billions of compounds against your target, then predict their engagement across the proteome.

3.4B compounds × 20,431 proteinsTop-ligand retrieval in 20 H100 GPU-hours, after library embedding. Reported in the preprint; predictions require experimental validation.

Roughly 5,000× higher throughput than Boltz-2*

03

Resolve predictions to individual sites

Test both which compounds engage a target and where, with predictions resolved to individual sites.

* In the reported EGFR benchmark on one H100, measured over batched runs.

02 / Native-cell profiling

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MARMOT

A functional proteomics technology powering Ptarmigan that measures proteins in their native context. Reports how compounds bind and alter protein localization in living human cells.

Treat native human cells
Profile protein dynamics
Measure compound–protein interactions at scaleChange in chromatin association
Assay schematic; illustrative readouts.
01

Profile complex protein dynamics

Track how proteins redistribute in response to compounds, preserving the cellular context in which they function.

02

Measure protein responses to small molecules at scale

We have tested 200 million compound–protein pairs in living human cells.

03

Investigate engagement and mechanism

Combine changes in protein localization with site-resolved evidence from covalent compounds to investigate how a molecule acts.

03 / News

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04 / Who we are

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Our team

We build technology, models and molecules together in our lab in Seattle.

Let’s work onthe hard targets

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Bring a target, a question, or a discovery challenge. Explore how Ptarmigan-1 and native-cell profiling could advance your program.